Indeed, fitting of our HTNV Gn−Fab HTN-Gn1 complex crystal structure into the Fab HTN-Gn1-treated VLP reconstruction resulted in an excellent fit (correlation coefficient, 0.9), which unambiguously reveals the orientation of the Gn in this region of the spike complex, and reveals that the HTN-Gn1 epitope is proximal to the Gn-Gc interface (Fig. 4A). The gene discussed is GYG1; the disease is hypertensive disorder.