Sequence analysis revealed 10% divergence from germline for both the HTN-Gn1 and nnHTN-Gn2 heavy chains (V and J regions combined) and 12% and 5% divergence from germline for the HTN-Gn1 and nnHTN-Gn2 kappa chains, respectively (V and J regions combined) (Fig. S2 and Table S1). The gene discussed is GYG1; the disease is hypertensive disorder.