MBD2 and infection: Infection by viruses that replicate in the cytoplasm, such as enterovirus 71 (EV71), HCV, ZIKV, and porcine epidemic diarrhea virus (PEDV), affects the expression and localization of methyltransferases and demethylases to facilitate their RNA m6A modifications, which influences viral replication (37, 38, 50, –, 52).