Moreover, our finding that reproductive period was associated with levels of P-tau, but not to T-tau, suggests that the effects observed probably occurred at a preclinical stage of AD, before general neurodegeneration.47,48 P-tau is generally believed to be a more specific marker for AD pathology than T-tau, which is more related to unspecific neurodegeneration.47,48 Our findings therefore suggest that reproductive period is more related to AD pathology than to general neurodegeneration. This evidence concerns the gene MAPT and Alzheimer disease.