A proinflammatory profile of colonic CD4+CD103+ T cells in IBD flares has been observed,12,13 but the functional profile of intestinal CD8+CD103+ T cells is still not completely elucidated.14, 15, 16 Interestingly, in mice adoptive transfer of CD8+CD103+ T cells reduced the severity of ileitis.17 This evidence concerns the gene CD8A and inflammatory bowel disease.