These previous publications and our data suggest that ECP‐overexpressing T cells and ECP‐containing exosomes cooperate with the aforementioned proinflammatory cytokines/chemokines to induce nephritis, arthritis, and hepatitis in Lck‐ECP–transgenic mice and maybe also in human SLE patients. Here, RNASE3 is linked to systemic lupus erythematosus.