MMP3 is a kind of stromelysin and breaks down many extracellular matrix components, such as proteoglycans, fibronectin, laminin and collagen types III, IV, and V. Yu Jin et al. [29] reported that a high level of MMP3 expression in OSCC tissues was also correlated with tumor metastasis and poor prognosis of OSCC patients. This evidence concerns the gene FN1 and neoplasm.