SHMT2 is implicated in neoplasia and is associated with the expression of CD274 molecule (CD274), CKLF-like MARVEL transmembrane domain containing 6 (CMTM6), V-set immunoregulatory receptor (VSIR), V-set domain containing T cell activation inhibitor 1 (VTCN1), snail family transcriptional repressor 2 (SNAI2), and bone marrow stromal cell antigen 2 (BST2) in the tumor microenvironment of OSCC. The gene discussed is BST2; the disease is neoplasm.