A five genes (DES, RANBP17, CLEC5A, HOXC11, POSTN) risk score was constructed using WGCNA and Cox regression with The AUC for 1, 3, 5-year-survival were 0.771, 0.808, and 0.838, respectively[47]; another work used combined elevation of AURKB and UBE2C to predict severe outcomes and therapy resistance in glioma, and the AUC reported were 0.875 and 0.849 [48]. This evidence concerns the gene HOXC11 and central nervous system cancer.