The present study confirmed that, similar to inhibition of EGFR, overexpression of Notch2 blocks phosphorylation-mediated activation of the downstream AKT/mTOR pathway and thus increases the radiosensitivity of NPC cells, suggesting that Notch2 also has a regulatory role in the AKT/mTOR signaling pathway. This evidence concerns the gene AKT1 and nasopharyngeal carcinoma.