In contrast, Wang et al. examined the protein level of Notch2 in tumor and adjacent normal tissues from 184 colorectal cancer patients and found that the level of Notch2 protein was lower in tumor tissues than in adjacent normal tissues, suggesting that low expression of Notch2 protein might be an indicator of poor prognosis in colorectal cancer [10]. This evidence concerns the gene NOTCH2 and colorectal cancer.