Moreover, studies of CaSR function in anterior pituitary cells have shown that CaSR activation may enhance pituitary hormone secretions, including ACTH and PTHrP from AtT20 cells (Ferry et al. 1997, Mamillapalli & Wysolmerski 2010); growth hormone (GH) secretion from rat somatotrophs (Zivadinovic et al. 2002); and enhancement of GH-releasing hormone (GHRH)-mediated GH secretion in human non-functioning pituitary adenoma and GH-omas (Romoli et al. 1999). The gene discussed is GHRH; the disease is pituitary gland adenoma.