In the acute phase, administration of the CB2 agonist was not able to preserve the rapid loss of cancellous bone, which differs from rodent models of ovariectomy-induced osteoporosis where significant bone preservation was seen after 19 days of continuous administration of a CB2 agonist.24,25 MicroCT analysis of the proximal tibiae and distal femurs showed SCI causes a significant reduction in trabecular bone density with trabecular separation. The gene discussed is CNR2; the disease is osteoporosis.