With regards to the growth phase, we found that the rate of growth in aggregate number was only slightly associated with the concentration of inoculated tau seeds (Fig. 2C and G) and was (i) unaffected by an antibody-mediated reduction in tau seeds and (ii) independent of the seeding capability across Alzheimer’s disease cases. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.