The ‘cytokine storm’ of proinflammatory cytokines such as IL-6 and TNF-αobserved in COVID-19, in addition to amyloid beta (Aβ) and phosphorylated tau, resembleprocesses of the pathogenesis of Alzheimer’s disease and inflammatory response observedpost-surgery. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.