Theconsequences of the endosomal or lysosomal entry into cytosol could have seriousimplications that could lead to dysregulated lysosomal clearance and autophagy that couldcause the impaired clearance and thus the accumulation of misfolded proteins such as Aβ,Tau, or alpha synuclein, proteins implicated in Alzheimer’s disease or Parkinson’sdisease. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.