In order to study the effect of exercise on native human ⍺-synuclein protein species, we utilized the NL5901- pkIs2386 worm model of Parkinson’s which contains human ⍺-synuclein tagged to a yellow fluorescent protein (YFP) in the muscle cells (van Ham et al. 2008). The gene discussed is SNCA; the disease is Parkinsonism.