These results show that AC-YVAD-CMK could decrease the expression of NLRP1 inflammasome, inhibit the pyroptosis of renal tubular epithelial cells mediated by inflammasome pathway, and relieve the release of inflammatory factors IL-1β and IL-18 induced by NLRP1 inflammasome, showing a protective effect on sepsis-induced acute kidney injury. The gene discussed is IL1B; the disease is Sepsis.