CACNA1C and Schnyder corneal dystrophy: The discovery of CACNA1C-encoded LTCC mutation in JWSs manifested that LOF perturbations in cardiac LTCC could have drastic phenotypic implications, such as male predominance, accentuated J waves, and ST-segment elevation when bradycardia or pauses happen, relative shortened QTc interval, unexplained syncope, and SCD (18).