HspA4 (a non-canonical Hsp70 member), HspA5 (an Hsp of the endoplasmic reticulum (ER) also referred to as Grp78), and HspA9 (a mitochondrial Hsp also referred to as Grp75) (Figure 4) have been demonstrated to activate Akt in cancer models (87–90). The gene discussed is HSPA1A; the disease is cancer.