1. Hsp90 antibody levels rise 16-fold under stress (potential CVD biomarker?)2. Hsp90 supports Akt signalling (elevated Hsp90 and Akt levels have been reported in hypoxia challenged cardiomyocytes)3. Hsp90 possesses anti-apoptotic effects on hypoxia-mediated cardiomyocyte damage4. Cardiac Hsp90 supports protein maturation and has roles in the development of mutation-related cardiac arrhythmia5. Hsp90 regulates angiotensin II-induced cardiac hypertrophy. This evidence concerns the gene AKT1 and cardiac hypertrophy.