Major hallmarks of AD are two protein aggregates found in the brain; β-amyloid (Aβ) forming extracellular senile plaques (SPs) and Tau proteins forming neurofibrillary tangles (NFTs) inside the cell (Kidd 1963; Ittner and Götz, 2011; Panza et al., 2019). Here, MAPT is linked to Alzheimer disease.