RHO and cancer: The rapid proliferation and migration of cancer cells depends on signaling cascades regulated by many different Ras and Rho family members, resulting in increased expression of small GTPases in the Ras and Rho families in malignant cells (Gómez del Pulgar et al., 2005; Konstantinopoulos et al., 2007; Alan and Lundquist, 2013; Haga and Ridley, 2016; Porter et al., 2016; Wong et al., 2018).