In contrast to the RabL31–36 protein that arises by truncation (Nissim et al., 2019), the abnormal Rab22a proteins that occur in osteosarcoma are fusion proteins consisting of the first 1–38 amino acids of Rab22a followed by various sequences encoded by different regions of chromosome 20 (Liao et al., 2020). The gene discussed is RAB22A; the disease is osteosarcoma.