KRAS and Hypertension: Intriguingly, K-Ras knockout mice with spatiotemporally controlled expression of H-Ras by the K-Ras promoter have their embryonic lethality restored but develop dilated cardiomyopathy associated with arterial hypertension at an older age, reflecting the different molecular functions of Ras isoforms in the cell (Potenza et al., 2005).