Moreover, the ORP5 mRNA level is significantly elevated in tumors harboring oncogenic mutant K-Ras compared with tumors with wild-type (WT) K-Ras in cohorts of pancreatic cancer, NSCLC, and 33 types of cancer in the TCGA (the Cancer Genome Atlas) database (Kattan et al., 2019). This evidence concerns the gene OSBPL5 and familial pancreatic carcinoma.