Moreover, the ORP5 mRNA level is significantly elevated in tumors harboring oncogenic mutant K-Ras compared with tumors with wild-type (WT) K-Ras in cohorts of pancreatic cancer, NSCLC, and 33 types of cancer in the TCGA (the Cancer Genome Atlas) database (Kattan et al., 2019). The gene discussed is KRAS; the disease is cancer.