Finally, proteasome inhibition with bortezomib in human prostate cancer cells, and immortalized mouse embryonic fibroblasts promoted autophagy activation and upregulated expression of ATG5 and ATG7, which depended on phosphorylation of eIF2α, a downstream element of the PERK arm of the UPR (Zhu et al., 2010). This evidence concerns the gene ATG5 and Familial prostate cancer.