Although E-cadherin, a surface marker of epithelial cells, can effectively reflect the tightness of contact between cells and the spread of tissue cells to distant organs and tissues (Giannelli et al., 2016) (Yang et al., 2018) (Gan et al., 2016), our research indicates that RIPK4 is not related to E-cadherin in HCC. This evidence concerns the gene RIPK4 and hepatocellular carcinoma.