Of the composite outcomes, complete remission (CR), total remission (TR), partial remission (PR), and flare are used most frequently followed by changes from baseline in UPCR, eGFR, anti-dsDNA antibody level, complement 3 (C3) level, and complement 4 (C4) level, which are used to evaluate urine protein, renal function, and lupus serological activity, respectively. This evidence concerns the gene C3 and systemic lupus erythematosus.