In the high-angiogenetic GEC1 group, increased expressions of PDGFB, TGFB2, ADAM17, and ITGB8, and reduced expression of S1PR1 are linked to glomerular angiogenesis and glomerulosclerosis, whereas the increased expression of presenilin-1 and the decreased expressions of SERPINE1 and EFNB2 in glomerular endothelial cells correlate to the downregulation of angiogenesis. Here, S1PR1 is linked to glomerulosclerosis.