We found that HLA-B*44:03 (carrier frequency: p = 0.002, Pc = 0.02, OR = 8.8; gene frequency: p = 0.001, Pc = 0.01, OR = 7.5) and HLA-DQB1*04:02 (carrier frequency: p = 0.01, Pc = 1.08, OR = 11.4; gene frequency: p = 0.003, Pc = 0.03, OR = 12.6) were significantly associated with cases of dipyrone-related SJS/TEN with SOCs in the Brazilian population of European ancestry. This evidence concerns the gene HLA-B and toxic epidermal necrolysis.