Deletion of lysine 210 (ΔK210) in TNNT2 gene has been found to cause familial dilated cardiomyopathy (DCM) (Kamisago et al., 2000), which is characterized by dilated ventricular chamber and reduced systolic function leading to progressive heart failure with high mortality (Du et al., 2007; Kimura, 2010; Sfichi-Duke et al., 2010). Here, TNNT2 is linked to familial dilated cardiomyopathy.