Consistent with our results, survey of microarray datasets in Gene Expression Omnibus (GEO) has revealed that XIRP1 downregulated in failing hearts from human patients with diabetic or non-diabetic heart failure (GDS4314), and idiopathic DCM (GDS651) (Wang et al., 2014). The gene discussed is XIRP1; the disease is familial dilated cardiomyopathy.