Therefore, we first subjected these total 19 downregulated miRNAs to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis (Vlachos et al., 2015), resulting in several significant cancer-associated pathways, such as extracellular matrix (ECM)–receptor interaction, Wnt signaling pathway, and PI3K–Akt signaling pathway (Figure 6A). This evidence concerns the gene AKT1 and cancer.