The second part, a number of versatile RBPs [such as YBX1, Ago2, MVP, HuR, heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), lupus La protein, and EWI-2] have a positive influence on the encapsulation of one or several sEV-miRNAs (McKenzie et al., 2016; Mukherjee et al., 2016; Shurtleff et al., 2017; Teng et al., 2017; Gao et al., 2019; Temoche-Diaz et al., 2019; Fu et al., 2021). This evidence concerns the gene HNRNPA1 and systemic lupus erythematosus.