Figure 9 shows the PPI network of IER5 and its potential co-expression genes within the IER5-related DEGs. Nine pathways, including pathways related to P53, MTORC1 signaling, KRAS signaling, angiogenesis, the cell cycle, the cell cycle G1 S phase transition, the response to ionizing radiation, DNA double-strand repair and hypoxia, exhibited remarkably differential enrichment in the IER5-high expression phenotype, indicating the potential role of IER5 in the onset of glioma. This evidence concerns the gene TP53 and central nervous system cancer.