Increasing genetic evidence in 22q11.2 deletion syndrome, NS, and glioma tumors point toward the negative health impact of Lztr1 mutation or deletion in multiple organ systems, including the brain (Kurahashi et al., 1995; Frattini et al., 2013; Yamamoto et al., 2015; Johnston et al., 2018). The gene discussed is LZTR1; the disease is central nervous system cancer.