TET2 and systemic lupus erythematosus: Among the genes activated by high salt concentrations and involved in T cell differentiation and activation, spn is directly regulated by Tet2, and this relationship may provide a novel treatment for SLE by controlling a high-salt diet and intervention with Tet2-mediated Tfh cell differentiation (Ichiyama et al., 2015; Wu et al., 2016; Yang et al., 2016).