AKT1 and glaucoma: Moreover, mutations in OPTN encoding for the mitophagy adaptor protein optineurin (Rezaie et al., 2002; Wong and Holzbaur, 2014), TBK1 encoding the serine threonine protein kinase TANK-binding kinase 1 involved in autophagy (Sears et al., 2019), and OPA1 (Aung et al., 2002; Yu-Wai-Man et al., 2010; Guo et al., 2012) have been associated with glaucoma, thus highlighting a crucial role for mitochondrial dynamics and mitophagy pathways in glaucoma pathogenesis (Ito and Di Polo, 2017).