In vivo, cortical astrocytes reproduced a neurogenic response in transgenic mice with Rbpj-κ-depleted astrocytes submitted to traumatic brain injury (Zamboni et al., 2020) and reactive astrocytes activated a neurogenic program after stroke in Notch-depleted striatal astrocytes transgenic (Magnusson et al., 2020; Santopolo et al., 2020). The gene discussed is RBPJ; the disease is Stroke.