In fact, a lot of studies have found that the expression levels of collagen corresponding genes including COL1A1 were increased in SSc fibroblasts, and inhibiting collagen genes expression or collagen proteins production could be an effective treatment for the tissue fibrosis of SSc (Hitraya and Jimenez, 1996; Jimenez and Saitta, 1999; Sandorfi et al., 2005; Piera-Velazquez et al., 2020; Shi et al., 2020). Here, COL1A1 is linked to systemic sclerosis.