Furthermore, we found that some ITGs such as ITGA3, ITGA6 ITGA11, ITGB4, ITGB6, etc. were frequently upregulated in human cancers, whereas ITGs including ITGA1, ITGA7, ITGA8, ITGA9 and ITGB3, etc. were usually downregulated (Figure 1D). This evidence concerns the gene ITGA3 and cancer.