Furthermore, we found that some ITGs such as ITGA3, ITGA6 ITGA11, ITGB4, ITGB6, etc. were frequently upregulated in human cancers, whereas ITGs including ITGA1, ITGA7, ITGA8, ITGA9 and ITGB3, etc. were usually downregulated (Figure 1D). Here, ITGB3 is linked to cancer.