iNOS dependent anti-tumor TAMs skew the TME towards cytotoxicity through stimulating Th1 responses via secretion of CXCL9 and CXCL10, inducing cytotoxic CD8s through TNFα and IL1β, and direct killing of tumor cells through nitric oxide (NO) and Reactive Oxygen Species (ROS). This evidence concerns the gene IL1B and neoplasm.