The tumor microenvironment consists of non-tumor cells, such as endothelial cells, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), tumor-associated neutrophils (TANs), and various other cells, as well as cytokine interferon α (IFN-α), TNF, IL-1β and IL-6 to sustain an inflammatory environment (33). This evidence concerns the gene TNF and neoplasm.