Meanwhile, in the lower half of the plot, the viral infections related processes HPV (Tcf7, Fzd4, Itga4, Tcf7, Tnf, etc.)and HIV (Xpo1, Npm1, Nup50, Nup153, Nup160, Nup205, etc.), and the p53 signaling (Dusp5, Ddit4, Ccng1, etc.)are over-represented by downregulated genes (Figure 5C and Supplementary Table 5). This evidence concerns the gene DDIT4 and viral infectious disease.