The integration of the in silico approach of the lncRNAs-EVT and their associated pathways, with the host transcriptome derived from our model, reveals a network of gene-pathways closely related with KSHV oncogenesis: Integrins in angiogenesis, KSHV infection, signaling by PDGF, HIF1-signaling pathway or MicroRNAs in cancer were represented by upregulated genes such as Egfr; Vegfa, Hif1a, Dicer1, Zeb1, Zeb2, Rb1, or Il6. This evidence concerns the gene ZEB2 and cancer.