In addition, one of the distinctive pathways of the in vitro to in vivo transition dependent of KSHV, provided by the lncRNA targets, was Extracellular Matrix Organization and Activation of Matrix Metalloproteinases, overrepresented by the MMPs Mmp2, Mmp9, Mmp13, and Mmmp14. MMPs are associated with KS and may contribute to the mechanism of KS tumor growth. Here, MMP2 is linked to neoplasm.