H19 and Meg3 are upregulated during the transition in vitro to in vivo in the presence of KSHV (KSHV (+) tumors versus KSHV (+) cells), but in this same transition in the absence of KSHV these lncRNAs are not upregulated (KSHV (−) tumors versus KSHV (−) tumor cells). The gene discussed is MEG3; the disease is neoplasm.