On the other hand, small RNA-sequencing and miRNA analysis revealed a high proportion of upregulated host miRNAs dependent of KSHV infection, indicating that the presence of KSHV has a significant impact on the metabolism of host miRNAs, whose target genes are mainly associated to angiogenesis, ECM, spliceosome, p53 signaling, viral infections, and cell cycle control. Here, TP53 is linked to viral infectious disease.