Meanwhile, in the lower half of the plot, the viral infections related processes HPV (Tcf7, Fzd4, Itga4, Tcf7, Tnf, etc.)and HIV (Xpo1, Npm1, Nup50, Nup153, Nup160, Nup205, etc.), and the p53 signaling (Dusp5, Ddit4, Ccng1, etc.)are over-represented by downregulated genes (Figure 5C and Supplementary Table 5). Here, ITGA4 is linked to viral infectious disease.