Previous experiments have shown that HCP5 can participate in regulating various tumors, such as HCP5, which was mediated by transforming growth factor β (TGF β) and regulated by recombinant SMAD family member 3 (SMAD3) transcription, could promote the growth and metastasis of lung adenocarcinoma (LUAD) tumors (40). This evidence concerns the gene SMAD3 and lung adenocarcinoma.