To further verify the potential involvement of TRIM58 upregulation in proliferation and invasion ability of human papillary thyroid cancer, specific short hairpin RNAs against TIRM58 (shTRIM58) were applied to interfere TRIM58 expression in Con and AUF1-knockdown IHH4 and TPC1 cells, respectively. Here, TRIM58 is linked to thyroid gland papillary carcinoma.