In overall, we suggest that AUF1 may regulate the expression of ZBTB2 by binding to ZBTB2 3’-UTR, affecting the stability of ZBTB2 mRNA, which in turn affects the expression of TRIM58 and regulates the proliferation, migration, and invasion of papillary thyroid cancer cells. The gene discussed is ZBTB2; the disease is thyroid gland papillary carcinoma.