We observed significant enrichment of DNA damage repair (DDR)-related pathways in the subgroup with ROS1 mutation compared to the wild-type counterpart, including BRCA-centered network, ATP pathway, DNA repair pathway, and mismatch repair pathway (Figures 4B–E), indicative of an upregulation of the activity of DDR-related pathways secondary to the accumulation of gene damage and the elevated tumor antigenicity in the ROS1 mutated population. The gene discussed is ROS1; the disease is neoplasm.