The focus on ROS1-rearranged NSCLC on the one hand contributes to the tremendous success of tyrosine kinase inhibitors targeting the ROS1 rearrangement, whereas on the other hand leads to the neglect of the therapeutic potential behind the ROS1 alterations other than rearrangement, particularly de novo mutation that accounts for a larger proportion. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.