In TMA, VM frequently occurred in NSCLC tissues with ACE2 high level in the form of regular and integrated small pipes or large blood lakes (Figure 1A), and the majority of ACE2+/VE-cadherin+/EphA2+ cells were assembled into them; howbeit immature and discontinuous CD34+ (regarded as an endothelial marker) MVs were easily caught in ACE2 low expressing tissues. The gene discussed is CDH5; the disease is non-small cell lung carcinoma.