Moreover, we checked the expression of several genes that were previously reported to be affected by YK-4-279 in Ewing’s sarcoma (32, 33) and found that the expressions of TERT and UBE2C (Ubiquitin Conjugating Enzyme E2-C) were reduced after YK-4-279 treatment in our cell lines (Figure 5F). The gene discussed is UBE2C; the disease is Ewing sarcoma.