Grade 3 or 4 treatment-related AEs in the anti-PD-1+C group included hypothyroidism (n=3, 6.5%), rash (n=2, 4.3%), and hepatitis (n=1, 2.2%), while only 1 patient had 3-4 grade hepatitis in the C group. The gene discussed is PDCD1; the disease is hepatitis A virus infection.