Many previous studies have investigated the role of preoperative systemic inflammatory markers in CRC prognosis, including the Glasgow prognostic score (GPS), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein to albumin (CAR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and systemic organ score (SIS) (9–13). The gene discussed is CRP; the disease is colorectal carcinoma.