CEACAM5 and colorectal cancer: The studies had investigated that the carcinoembryonic antigen (CEA) targeted fluorescent imaging was successfully used in both pancreatic and colorectal cancer (9), In 2018, the carcinoembryonic antigen related cell adhesion molecule5 (SGM-101) fluorescent probe was used in the diagnosis of pancreatic cancer and the metastases, with an accuracy of 84% and sensitivity of 98% (10).