In conclusion, an immunosuppressive state in A-DLBCL may be described by both high levels of PD-L1+, mPD-L1+, CD33+, CD163+ and GATA3+ cells and low levels of CD8+ and PD-1+cells in the TIME; these TIME features could highlight key molecular markers of the prognosis of A-DLBCL, which is poorer than that of ordinary DLBCL. This evidence concerns the gene CD8A and diffuse large B-cell lymphoma.