Emerging research has shown that M2-like TAMs expressing PD-L1 correspond to the majority of immune cells in DLBCL and may play a role in tumor immune escape, angiogenesis, or matrix remodeling; in addition, a high M2-TAM level at diagnosis may be an unfavorable prognostic factor in DLBCL patients (53). This evidence concerns the gene CD274 and neoplasm.