Potassium voltage-gated channel subfamily A member 3 (KCNA3) can regulate neurotransmitter release, neuronal excitability, epithelial electrolyte transport, heart rate, insulin secretion, smooth muscle contraction and cell volume, and is involved in the immune modulation of memory T cell-mediated autoimmune diseases and auto-reactive effector (38, 39). Here, INS is linked to autoimmune disease.