TMPRSS2 and gastric cancer: Whole-Genome sequencing showed that TP53, ARID1A, TGFBR2, CDH1, SYNE1 and TMPRSS2 were significantly mutated genes in 49 patients with advanced-stage gastric cancer (3), and that TP53, ARID1A, CDH1 are a common set of genetic mutations related to the diffuse subtype of gastric cancer from various studies (3–5).