B2M and neoplasm: TAPBP, a member of the TAP family, has the strongest negative correlation with METTL14. Inconsistent with our results, previous studies have shown that TAPBP participates in the antigen presentation pathway, mediates the immune process, and inhibits tumor proliferation (57), suggesting complex interaction mechanism between METTL14 and TAPBP. B2M was the only MHC gene that was significantly positively correlated with METTL14. Several studies have reported that the loss or mutation of the B2M gene was one reason for tumor immune escape.