The analysis of the expression of m6A-related genes in rectal cancer showed that the expression levels of KIAA1429, METTL3, METTL16, and HNRNPA2B1 were higher and the expression levels of METTL14 and ALKBH5 in rectal cancer were significantly lower than those in normal tissues, showing that aberrant expression of m6A regulatory genes commonly occurs in rectal cancer. Here, METTL16 is linked to rectal cancer.