Interestingly, TNFRSF25 plays a complex dual role in tumors: on the one hand, it binds to its ligand TL1A to activate T cells and inhibit tumor progression (48); on the other hand, through the PI3K/NF-kB pathway, it can reduce the apoptosis of colon cancer cells and promote tumor proliferation and metastasis (49). Here, TNFSF15 is linked to malignant colon neoplasm.