Besides the data sets without the statistically significant difference, the results showed that compared to normal tissues, the expression levels of KIAA1429, METTL3, METTL16, and HNRNPA2B1 increased in rectal cancer, and the expression of METTL14 and ALKBH5 in rectal cancer was significantly decreased. This evidence concerns the gene METTL16 and rectal cancer.