Using the TIMER, GEPIA, and TISIDB databases, our results revealed the positive correlation of the expression level of METTL14 with the immune infiltration level in rectal cancer, including gene signature of CD8+ T cell, CD4+ T cell, B cell, DCs, macrophages, neutrophils and Th2, which were consistent in at least two databases mentioned above. The gene discussed is CD8A; the disease is rectal cancer.