Besides the data sets without the statistically significant difference, the results showed that compared to normal tissues, the expression levels of KIAA1429, METTL3, METTL16, and HNRNPA2B1 increased in rectal cancer, and the expression of METTL14 and ALKBH5 in rectal cancer was significantly decreased. The gene discussed is ALKBH5; the disease is rectal cancer.