IGF1 and Insulin resistance: This results in hyperglycemia secondary to insulin resistance and hepatic gluconeogenesis, enhanced immune response and increased lipolysis [1,2,4-6,10,12]. In addition to fatty acids being utilized as an energy source, increased proteolysis from skeletal muscle supplies 30% of calories needed to support the resting energy expenditure which can increase by as much as 40-60% [1,3,5,6,13,14]. The anabolic effects of GH such as amino acid uptake and protein synthesis are indirectly achieved via insulin-like growth factor (IGF-1) or somatomedin C, a product of hepatic synthesis [3, 5, 9].