Topological analysis identified many key mRNAs/lncRNAs implicated in the regulation of diverse immune-related processes in response to ABPA and asthma (the frequency of counting as top 20 hub nodes among 12 algorithms ≥ 3, Table 3, details see Supplementary Methods), including five lncRNAs, namely AL139423.1-201, AC106028.4-201, HNRNPUL1-210, PUF60-218 and SREBF1-208, and five known mRNAs (PRR14L-201, CCRL2-202, GDAP2-202, SPAG1-206, SLC35B2-207). The gene discussed is SPAG1; the disease is asthma.