NFKB1 and neoplasm: First, miR-195-5p has been found to suppress tumor by decreasing the expression of multiple NF-κB downstream effectors by directly targeting nuclear factor kappa-B kinase subunit alpha (IKK α) and transforming growth factor-beta(TGF-β)-activated kinase 1 and MAP3K7-binding protein 3 (TAB3)(Ding et al., 2013).